Hi rradiogirl,
I find I
have to the multivitamin with food, otherwise it upsets my tummy

. The doc says that's best anyway.
As far as B6 goes, separating from other vitamins won't hurt, but I am not sure that it is necessary. But I would take it with food to help move it through your digestive track. It is absorbed in the middle and lower parts of the small intestine.