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Old 02-05-2012, 03:45 PM   #13 (permalink)
VitoVino
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Default Furthermore...

... to claim that "There are no documented studies confirming the claimed side effects of aspartame." is misleading. There are studies which


Quote:
The effects of aspartame have been studied on various
species, including humans, rats, mice and rabbits. Most
studies described in the literature have a macroscopic
approach. If no adverse effects are visible after a single large
administered dose of aspartame, it is believed that aspartame
has no effect. Further studies are not carried out microscopically
to demonstrate possible adverse effects on the
cellular basis.
Thus, results obtained from different studies
vary from severe adverse effects to none observed.
The aim of this study was to investigate the direct and
indirect cellular effects of aspartame on the brain, and
we propose that excessive aspartame ingestion might be
involved in the pathogenesis of certain mental disorders

(DSM-IV-TR 2000) and also in compromised learning and emotional functioning.
Quote:
Conclusion

It was seen that aspartame disturbs amino acid metabolism,
protein structure and metabolism, integrity of nucleic acids,
neuronal function, endocrine balances and changes in the
brain concentrations of catecholamines. It was also reported
that aspartame and its breakdown products cause nerves to
fire excessively, which indirectly causes a very high rate of
neuron depolarization.
The energy systems for certain
required enzyme reactions become compromised, thus
indirectly leading to the inability of enzymes to function
optimally. The ATP stores in the cells are depleted, indicating
that low concentrations of glucose are present in the cells,
and this in turn will indirectly decrease the synthesis of
acetylcholine, glutamate and GABA. The intracellular calcium
uptake has been altered
, thus the functioning of glutamate as an excitatory neurotransmitter is inhibited.

Mitochondria are damaged, which could lead to apoptosis of
cells and infertility in men and also a lowered rate of
oxidative metabolism are present, thus lowering concentrations
of the transmitters glutamate and production of GABA.
The cellular walls are destroyed; thus, the cells (endothelium
of the capillaries) are more permeable, leading to a
compromised BBB. Thus, overall oxidative stress and neurodegeneration
are present. From all the adverse effects caused by this product, it is
suggested that serious further testing and research be
undertaken to eliminate any and all controversies surrounding
this product.

http://www.newmediaexplorer.org/sepp/aspartamebrain.pdf
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