I started eating Paleo/Primal on September 1st. It has not been easy, but it has been "doable." The main problem I have found has been the convenience factor. This lifestyle requires "real" foods, i.e., not processed. But real foods are oftentimes a lot more work to prepare than prepackaged off the shelf type fare.
Having said all that, I've noticed great results. I'm 38 years old, 6'4" and currently weigh 206 pounds. In one month, I've lost 9 pounds and two inches from my waist. (I've also increased my exercise during this period, but I attribute most of the weight loss to diet change.) Also, before starting this way of eating, I had to take omeprazole daily to control my heartburn. After about a week, I stopped taking the omeprazol and I have not had a single instance of heartburn.
The scientific studies on this diet seem to support what I've discovered on this diet. I.e., you will lose weight, feel better and have overall improved health.